Publikationen der AG Prof. Runkel
Publikationsliste (Peer-reviewed Articles)
Book chapters
2010
T Jünemann, A Reeg, J Amborn, R Engelhard, F Runkel (2010) „Einführung eines QM-Systems nach DIN EN ISO 9001:2000 und DIN EN ISO 13485:2005 in einem mittelständischen GMP-Betrieb“. GMP-/FDA-Anforderungen an die Qualitätssicherung: Qualitätssicherungssystem, GMP-Compliance, Lieferantenqualifizierung, GMP-relevante Verträge.
1999
J Amborn, F Runkel (1999) „Qualitätskontrolle in der pharmazeutischen Industrie.“ Pharmaka V - Forschung und klinische Anwendung Steinkopff-Verlag (Darmstadt).
Conference papers
2018
M Schuppe, C Kiselmann, D Dobler, A Wacker, O Schmidt, F Runkel, T Schmidts, W Pfützner, C Möbs „Epidermal allergen-specific immunotherapy in an Api m 1-allergic mouse model“. Allergo J Int (2018) 27: 25.
2015
R Ibrahim, U Purath, A Turowska, U Homburg, F Runkel, T Schmidts, D Dobler, H Renz, H Garn, A Müller “Effects of interference with GATA-3 expression by target-specific DNAzyme treatment on disease progression in a subacute oxazolone-induced mouse model of atopic dermatitis”. Clinical and Translational Allergy 2015 5 (Suppl 1):O21.
2012
U Mäder, T Bergmann, S Beer, J M Burg, T Schmidts, F Runkel, M Fiebich “Spectrally resolved visualization of fluorescent dyes permeating into skin”. SPIE Proceedings Volume 8225.
2011
J M Burg, M Völker, P Schlupp, T Schmidts, U Mäder, T Bergmann, F Runkel, J T Heverhagen, M Fiebich „Studying skin penetration by NMR imaging“. SPIE BiOS 78920V-78920V.
T Bergmann, S Beer, U Mäder, J M Burg, P Schlupp, T Schmidts, F Runkel, M Fiebich “Development of a skin phantom of the epidermis and evaluation by using fluorescence techniques”. SPIE BiOS 79060T-79060T.
S Beer, U Mäder, T Bergmann, P Schlupp, T Schmidts, J T Heverhagen, F Runkel, M Fiebich “Calibration phantom for the quantification of fluorescent labels in deep skin tissue”. European Conference on Biomedical Optics.
U Mäder, T Bergmann, J M Burg, S Beer, P Schlupp, T Schmidts, J T Heverhagen, F Runkel, M Fiebich “4D confocal microscopy method for drug localization in the skin”. European Conferences on Biomedical Optics 80861A-80861A.
2010
U Mäder, T Schmidts, J M Burg, J T Heverhagen, F Runkel, M Fiebich “Hardware and software system for automatic microemulsion assay evaluation by analysis of optical properties”. Proc. of SPIE Vol 762625-1.
2008
P Czermak, T Steinle, M Ebrahimi, T Schmidts, F Runkel “Membrane Assisted Production of S1P Loaded SLNs for the Treatment of Acne vulgaris”. Proceedings 12. Aachener Membran Kolloquium 2008 601-608 VIVTA Aachen.
2007
G Lavi, M Ebrahimi, T Schmidts, F Runkel, P Czermak “Development and Production of Oil-in-Water Vehicles Sub-micron Emulsion Using Tubular Ceramic Membranes” Proceedings 11. Aachener Membran Kolloquium 2007 579-585 Verlag Mainz, Aachen.
Conference Poster
2019
A Pössl, T Schmidts, F Runkel, P Schlupp “Cell therapy for the treatment of Diabetes Mellitus: The interplay between BioInk, cell culture and 3D-Printer”. The European CELLINK Collaborative Partnership Conference, Mailand (Italien), 10 May 2019.
2018
D Dobler, T Schmidts, F Runkel “Benzalkonium lactate as multifunctional ionic liquid for pharmaceutical applications”. 15th International Conference on Pharmaceutical Formulations & Drug Delivery, 17-18 September 2018, Philadelphia, USA.
A Pössl, P Schlupp, T Schmidts, F Runkel “3D-printed drug delivery systems for cell therapy: A new approach for the treatment of Diabetes Mellitus”. Dechema 3D Cell Culture 2018, Freiburg (Germany), 05-07 June 2018.
2017
F Höfer, T Schmidts, E Domann, F Runkel “LNAzymes cleaving Pseudomonas aeruginosa algD mRNA”. 7th Cambridge Symposium on Nucleic Acids Chemistry and Biology, Queens' College, University of Cambridge (United Kingdom), 3rd-6th September 2017.
C Sack, K Abraham, D Dobler, T Schmidts, F Runkel “Development of drug delivery systems for intradermal application of hymenoptera allergens”. Young Scientist Satellite Conference, and 6th FIP Pharmaceutical Sciences World Congress, Uppsala Stockholm (Schweden) 21-24 May 2017.
A C Eicher, S Beer, D Dobler, T Schmidts, F Runkel “Dermal DNAzyme delivery via chitosan hydrogels”. Young Scientist Satellite Conference and 6th FIP Pharmaceutical Sciences World Congress, Uppsala Stockholm (Schweden) 21-24 May 2017.
A C Eicher, K Marquardt, D Dobler, T Schmidts, F Runkel “Development of a competitive displacement assay for the characterization of polyplexes”. Annual Meeting CRS-Local Chapter Germany 2017, Marburg (Germany) March 2-3, 2017.
A Pössl, M Eisenhardt, P Schlupp, T Schmidts, F Runkel “An insect-based protein for the treatment of chronic wound infections”. Annual Meeting CRS-Local Chapter Germany 2017, Marburg (Germany) March 2-3, 2017.
2016
F Höfer, K Marquardt, T Schmidts, E Domann, F Runkel “DNAzymes combatting Pseudomonas aeruginosa biofilm formation”. The 12th Annual Meeting of the Oligonucleotide Therapeutics Society, Montreal (Canada), 25.09.2016 - 28.09.2016.
2015
M Eisenhardt, T Schmidts, P Schlupp, F Runkel “IMPI – a novel therapeutic for chronic wound infections” Gordon Research Conference: Antimicrobial Peptides, Lucca (Italy), May 3-8, 2015.
2014
F Höfer, M Dahlke, P Schlupp, T Schmidts, F Runkel “Porcine small intestine to study drug transport”. 26th meeting of European Intestinal Transport Group (EITG) Marstrand (Sweden), October 2‐5, 2014.
K Marquardt, S Kerker, A C Eicher, Z Kovacs, M Ebrahimi, T Schmidts, P Czermak, F Runkel “Diafiltration in a manufacturing process of liposome embedded DNAzymes”. 6th International Congress of Pharmaceutical Engineering, Graz (Austria), June 16th-17th, 2014.
D Dobler, T Schmidts, K Marquardt, F Runkel “Enzymatic degradation and protection of dermally applied DNAzyme”. 9th World Meeting on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology, Lissabon (Portugal), 31.03. - 03.04.2014.
D Dobler, C Zinecker, T Schmidts, F Runkel “Solubility of poorly soluble pharmaceutical compounds in Ionic Liquids”. 9th World Meeting on Pharmaceutics, Biopharmaceuticsand Pharmaceutical Technology, Lissabon (Portugal), 31.03. - 03.04.201.
2013
U Purath, R Ibrahim, A Turowska, U Homburg, F Runkel, T Schmidts, D Dobler, H Renz, H Garn, A Müller “Targeting of GATA-3 by DNAzymes as therapeutic approach for the treatment of atopic dermatitis” EAACI-WAO Congress 2013, Milan (Italy) 22-26 June 2013.
U Purath, R Ibrahim, A Turowska, U Homburg, F Runkel, T Schmidts, D Dobler, H Renz, H Garn, A Müller “GATA-3 cleavage by DNAzymes as therapeutic approach for the treatment of allergic skin diseases” International Investigative Dermatology, Edinburgh (Scotland) 8th - 11th May 2013.
M Eisenhardt, D Dobler, T Schmidts, M Salzig, F Runkel “Thermo sensitive hydrogels as carrier systems for insect-based proteins in chronic wound management” 17. Jahrestagung der Gesellchaft für Dermopharmazie vom 21.-23.3.2013 im Universitätsklinikum Mainz (Germany).
P Schlupp, L Peuker, V Engelmann, R Sus, T Schmidts, F Runkel “Permeation of various drugs across the porcine small intestine and the Caco-2- model using the Ussing chamber technique“ 25th Congress of the European Intestinal Transport Group, 11th - 14th April 2013, Bad Herrenalb (Germany).
2012
S Beer, U Mäder, T Bergmann, J M Burg, M Fiebich, F Runkel “Quantifying fluorescence signals in confocal image stacks deep in turbid media”. Photonics West - Biomedical Optics: Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX, San Francisco, California (USA 21), January 2012.
R Thiele, J Engel, S Hühn, T Schmidts, F Runkel, K G Werner “Upscaling Nanosizing of Poorly water Soluble Drugs using various nanomills” 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology; Istanbul.
M Völker, J M Burg, P Schlupp, U Mäder, A M Koening, J T Heverhagen “Quantification of skin penetration with contrast-enhanced MRI at 7T”. Annual Meeting of the International Society of Magnetic Resonance.
P Schlupp, S Wildenhain, T Schmidts, F Runkel “Development of a permeation model using porcine small intestine”. Bad Herrenalber Transporter- und Barriere Tage, Bad Herrenalb 14.05. - 16.05.2012.
2011
K Marquardt, S Hühn, T Schmidts, F Runkel “Adaption of a SME for DNAzymes” International Congress of Pharmaceutical Engineering 2011 Graz.
D Dobler, T Schmidts, S Beer, F Runkel “In-process control of multiple W/O/W emulsions production using Impedance Spectroscopy” International Congress of Pharmaceutical Engineering 2011 Graz.
P Schlupp, A Gross, T Schmidts, F Runkel “Development of Pharmaceutical Submicron Emulsions using the Required HLB Approach”. International Congress of Pharmaceutical Engineering 2011 Graz.
A M Hug, T Schmidts, J Kuhlmann, D Segger, G Fotopoulos, J Heinzerling “Skin hydration and cooling effect produced by the Voltaren® Vehicle Gel”. Skin Forum 12th Annual Meeting.
2010
S Beer, U Mäder, T Schmidts, P Groß, C Fallnich, F Runkel, M Fiebich „Labelfreie Analyse von topisch applizierten Wirkstoffformulierungen mittels CARS-Mikroskopie“. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik e.V., DGBMT, 2010, 29.09. - 02.10.2010 Freiburg.
U Mäder, J M Burg, T Bergmann, P Schlupp, T Schmidts, F Runkel, M Fiebich „Semi-Quantitative Fluoreszenzauswertung von Wirkstoffen in Hautschnitten“. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik e.V., DGBMT, 2010, 29.09. - 02.10.2010 Freiburg.
U Mäder, T Schmidts, J M Burg, J T Heverhagen, F Runkel, M Fiebich “Hardware and software system for automatic microemulsion assay evaluation by analysis of optical properties” SPIE Medical Imaging, 13 - 18 February 2010, USA.
T Schmidts, D Dobler, P Schlupp, U Mäder, P Nocker, F Runkel “Phase Diagramm by Micro Plate Dilution (PDMPD) as a promising Tool for Microemulsion Development”. 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 8th to 11th March 2010, Malta.
U Mäder, J M Burg, T Schmidts, J Heverhagen, F Runkel, M Fiebich “Calculation of calibration factors for quantitative evaluation of flourescent dye concentrations in skin using Monte-Carlo simulations”. DGBMT, BMT 2010, Band 55, Heft s1, Seiten 24-27.
J M Burg, U Mäder, T Schmidts, FRunkel, M Fiebich “Development of a method for quantitative determination of fluorescence dyes in skin using widefield fluorescence microscopy”. DGBMT, BMT 2010, Band 55, Heft s1, Seiten 21-23.
2009
A Sieben, A Wolf, F Runkel, H Häberlein “Fluorescence correlation spectroscopy is a noninvasive technique for studying ligand-receptor interactions in live cells as shown for β2-adrenergic receptors”. 7. Berliner Kongress Phytotherapie 2009, 10.–12. September 2009 Berlin.
A Sieben, A Wolf, F Runkel, H Häberlein “α-Hederin from Hedera helix affects the binding behaviour of β2-adrenergic receptors as revealed by fluorescence correlation spectroscopy”. 7. Berliner Kongress Phytotherapie 2009, 10.–12. September 2009 Berlin.
A Wolf, A Sieben, F Runkel, H Häberlein “Influence of the saponins from Hedera helix on the β2-adrenergic responsiveness of living cells investigated by β2-adrenergic receptor internalization studies and determination of intracellular cAMP levels”. 7. Berliner Kongress Phytotherapie 2009, 10.–12. September 2009 Berlin.
D Dobler, T Schmidts, F Runkel “Influence of emulsifiers and preparation conditions on the properties of multiple emulsions Jahrestagung 2009 der Deutschen Pharmazeutischen Gesellschaft. 28. September - 1. Oktober 2009, Jena.
P Schlupp, T Schmidts, U Mäder, W Mehnert, M Fiebich, F Runkel “Solid Lipid Nanoparticles (SLN) - an innovative carrier system for Sphingosine-1-phosphate (S1P)” EuroNanoMedicine 2009, September 28-30, Bled, Slowenia.
F Runkel, M Ebrahimi, T Schmidts, P Czermak “Membrane Assisted Production of Sphingosine-1-Phosphate Loaded Solid Lipid Nanoparticles”. AIChE Annual Meeting, 8.-12.11.2009, Nashville, USA.
2008
P Czermak, T Steinle, M Ebrahimi, T Schmidts, F Runkel “Membrane Assisted Production of Sphingosine-1-Phosphate (S1P) Loaded Solid Lipid Nanoparticles (SLN) for Treatment of Acne vulgaris”. 12. Aachener Membran Kolloquium, 29.-30.10.2008.
2007
B Kleuser, T Schmidts et al. „Nanoderm-TS Nanopartikuläre Targeting-Systeme für die Dermatotherapie“. 3. BMBF-Symposium Nanobiotechnologie; 09. - 10.Oktober 2007, Hannover.
M Ebrahimi, G Lavi, T Schmidts, F Runkel, P Czermak “Development and Production of Oil-in-Water Vehicles Sub-micron Emulsion Using Tubular Ceramic Membranes” 11. Aachener Membran Kolloquium 2007, pp. 579-585, Verlag Mainz Aachen 2007.
2006
G Lavi, M Ebrahimi, T Schmidts, F Runkel, P Czermak “Development and Production of Oil-in-Water Vehicles Microemulsion for Dermal Application of Ectoin” AIChE 2006 Annual Meeting, November 12-17, 2006, San Francisco (USA).
2005
G Lavi, T Schmidts, F Runkel, P Czermak “Comparing the Preparation of Microemulsion containing Ectoin by Ceramic-Membrane to different shear dispersing emulsification methods”. Engineering with membranes: Medical and Biological Applications, Camogli, Italy, 15-18 May 2005.
F Runkel, P Czermak “Membranes in production of highly purified water for pharmaceutical and medical products - a review”. Engineering with membranes: Medical and Biological Applications, Camogli, Italy, 15-18 May 2005.
G Lavi, T Schmidts, F Runkel, P Czermak “Preparation of an oil-in-water microemulsion containing the compatible solute ectoin using ceramic membranes”. Engineering with membranes: Medical and Biological Applications, Camogli, Italy, 15-18 May 2005.
Conference Lectures (AG BPT)
C Kiselmann “Hydrophilic Ionic Liquids as Ingredients in gel-based dermal formulations.” 15th International Conference on Pharmaceutical Formulations & Drug Delivery, 17-18 September 2018, Philadelphia, USA.
M Eisenhardt “IMPI: A Novel Therapeutic for Chronic Wound Infections.” Gordon Research Seminar: Antimicrobial Peptides, Lucca (Italy), May 2-3, 2015.
T Schmidts „Multiple Emulsionen als Trägersysteme zum Schutz von dermal appliziertem DNAzym.“ 16. Jahrestagung der GD Gesellschaft für Dermopharmazie, 2012 Berlin.
P Schlupp “Optimizing conventional galenics: microemulsions as a paradigm” GD (Gesellschaft für Dermopharmazie) conference in Bonn "Development and Regulatory Aspects of Topical Dermatics Today"2010.
PhD theses
Christopher Kiselmann (2019) „Entwicklung und Charakterisierung von Trägersystemen zur dermalen Immuntherapie mit Hymenopterenallergenen.“ Justus-Liebig-Universität Gießen.
Frank Gregor Höfer (2018) „Entwicklung eines DNAzyms gegen Biofilm bildende Pseudomonaden bei Zystischer Fibrose“ Justus-Liebig-Universität Gießen.
Kay Marquardt (2016) „Entwicklung eines protektiven dermalen Drug Delivery Systems für therapeutische DNAzyme gegen Hauterkrankungen wie die aktinische Keratose.“ Philipps-Universität Marburg.
Sebastian Beer (2016) „Top-Down Analyse des Zustandes und des Herstellungsprozesses einer multiplen Emulsion.“ Philipps-Universität Marburg.
Michaela Eisenhardt (2016) „Der Insekten-Metalloprotease-Inhibitor IMPI zur Therapie von Wundinfektionen - Präklinische Untersuchungen und Formulierungsdesign.“ Philipps-Universität Marburg.
T Schmidts (2013) „Entwicklung innovativer Trägersysteme zur gezielten dermalen Applikation eines GATA-3-spezifischen DNAzyms als Therapeutikum der atopischen Dermatitis.“ Philipps-Universität Marburg.
F Runkel (1988) „Synthese neuer H2 Antagonisten mit N-Sulfamoylguanidinstruktur: Struktur und Wirkung.“ Universität Marburg.
Patent
C Kiselmann, C Möbs, T Schmidts, W Pfützner, F Runkel, C Zinecker (2019) „Mikroemulsion zur dermalen Hyposensibilisierung mit Allergenen“ Veröffentlichungsnummer DE 10 2018 113 509 A1.
F Runkel, T Schmidts (2013) „Multiple emulsion“ Veröffentlichungsnummer: WO2013020899 A1.
F Runkel, T Schmidts (2013) „Multiple Emulsion“ Veröffentlichungsnummer: DE102011109868 A1.
F Runkel, T M Schmidts (2011) „Novel formulation“ Veröffentlichungsnummer: US20110059985 A1.
T Schmidts, F Rukel (2009) “Novel Formulation (a hydrophilic nailgel for treating onychomycosis)” Veröffentlichungsnummer: WO2009053741 A2.
F Runkel, W Schneider, O Schmidt, G M Engelhard (2008) “Method for the production of a storage-resistant ivy leaf extract, and extract produced according to said method” Veröffentlichungsnummer: EP1663269 B1.
F Runkel, W Schneider, O Schmidt, G M Engelhard (2008) “Method for the production of ivy leaf extracts, and extract produced according to said method” Veröffentlichungsnummer: EP1663270 B1.
F Runkel, K - M Engelhard, G M Engelhard (2007) “Method for the production of an extract of ivy leaves” Veröffentlichungsnummer: EP1608388 B1.
F Runkel, K - M Engelhard, G Engelhard (2006) “Process for producing an extract of ivy leaves” Veröffentlichungsnummer: US20060057236 A1.
G M Engelhard, F Runkel, O Schmidt, W Schneider (2005) “Method for the production of a storage-resistant ivy leaf extract, and extract produced according to said method” Veröffentlichungsnummer: WO2005037299 A.
G M Engelhard, F Runkel, O Schmidt, W Schneider (2005) “Production of an ivy leaf extract with both rapid and prolonged action in treating respiratory diseases, comprises mixing a first ivy extract rich in hederacoside C with a second ivy extract rich in alpha-hederin” Veröffentlichungsnummer: DE10345343 A1.
F Runkel, W Schneider, O Schmidt, G M Engelhard (2005) “Producing an ivy leaf extract containing hederacoside C and alpha-hederin, useful for treating respiratory diseases comprises steaming comminuted ivy leaves before extraction” Veröffentlichungsnummer: DE10345342 A1.
G M Engelhard, K - M Engelhard, F Runkel (2004) “Method for the production of an extract of ivy leaves” Veröffentlichungsnummer: WO2004087183 A1.
F Runkel (2003) „Insect repellent“ Veröffentlichungsnummer: US6576223 B2.
F Runkel (2003) “Use of a medicine containing a quantity of tyrothricine for the treatment of viral infections” Veröffentlichungsnummer: EP1096942 B1.
F Runkel (2001) “Topical drug for the treatment of viral infections” Veröffentlichungsnummer: EP1096947 A1.
F Runkel (2001) „Verwendung eines Arzneimittels mit einem Gehalt an Tyrothricin zur Behandlung von Virusinfektionen“ Veröffentlichungsnummer EP1096942 A2.
F Runkel (1999) „Verwendung eines Arzneimittels mit einem Gehalt an Tyrothricin zur Behandlung von Virusinfektionen“ Veröffentlichungsnummer: DE19823318 A1.
F Runkel (1999) „Topisch anwendbares Arzneimittel zur Behandlung von Virusinfektionen“ Veröffentlichungsnummer: DE19823319 A1.
F Runkel (1999) “Use of a medicine containing a quantity of tyrothricine for the treatment of viral infections” Veröffentlichungsnummer: WO1999061011 A2.